Nabota botulinum toxin by daewoong are getting FDA approval

Nabota, the South Korean made botulinum toxin will be available in New Zealand, Israel and Ukraine as early as 2020 in accordance with the three separate contracts. Daewoong Pharmaceutical aims to launch Nabota in over 100 countries by 2020, Nobota is exported worldwide such as South Asia and South America.

– In one vial –
· Active ingredient: Clostridium botulinum toxin type A (standard) 100 units
· Other additives: human serum albumin 0.5mg, sodium chloride 0.9mg

nobota

nobota

[Effectiveness]

1. Temporary improvement of moderate to severe severe wrinkles associated with eyebrow corrugator muscle and / or procerus muscle activity in adults between 20 and 65 years of age

2. Muscle stiffness: Stiffness related to stroke in adults over 18 years of age.

[Usage capacity]

1. Wrinkles
Dilute to 100 U / 2.5 mL (4 U / 0.1 mL) with 0.9% non-preservative sterile saline solution. Using a 30-gauge injection needle, inject 20 mL of each eyebrow in 0.1 mL increments to each of the five corrugate muscles and one of the procures muscles.

Avoid injections near the levator palpebrae superioris, especially in patients with large eyebrow suppression muscles to reduce complications of ptosis. When injecting into the inner eyebrows and middle eyebrows, inject at least 1 cm away from the perimeter of the eye.

Be careful not to inject into the blood vessels when administering this drug. Place a thumb or index finger tightly under the perimeter of the eye before injection to prevent the exudation below the edge around the eye. During the injection, the needle should be directed to the upper middle, and the injection volume should be accurate.

The corrugate muscle and the orbicular-is muscle move in the middle of the forehead to make facial wrinkles. Procures muscle and depressor muscle pull the forehead down. These muscles produce distortions or wrinkles. Because muscle position, size, and use vary from person to person, effective dose is determined by total observation of the patient’s ability to operate implanted surface muscles.

The therapeutic effect of NSAID on wrinkles lasts approximately 3-4 months. The safety and efficacy of frequent dosing of NSAIDs has not been clinically evaluated and is not recommended.

In general, the first dose of the botulinum toxin formulation induces chemical denervation of the injected muscle after 1 or 2 days, and its intensity increases during the first week.

2. Muscle rigidity

The exact dose and number of injection sites may vary depending on the size, number and location of the involved muscles, the degree of rigidity, the presence of localized muscle weakness, and the patient’s response to prior treatment. Clinical improvement of muscle tone was observed at 4 weeks after injection and continued for 8 weeks and 12 weeks after injection.

In clinical trials, the dose did not exceed a maximum of 360 U, and was injected into each muscle separately.

A sterile 24-30 gauge needle is used for the surface muscle, and an appropriate length needle is used for deep muscle tissue. Induction of EMG and nerve stimulation techniques are useful for locating related muscles.

buy nabota online

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<Dilution method>
In order to dissolve the lyophilized pesticide, sterile physiological saline is used without preservative. 0.9% sodium chloride injection is recommended dilution. Add an appropriate amount of diluent to a suitable size syringe. Slowly add dilution to the vial as this drug will bloom or become highly denatured if a similar fluctuation occurs. This vial should be discarded if the diluent is not put into the vial under vacuum. Record the date and time of dissolution on the label and allow to be administered within 24 hours after dissolution. Store the diluted solution in a refrigerated state (2-8 ° C). When this medicine is dissolved, it should be colorless and transparent and free from foreign matter. Parenteral formulations should be carefully examined for foreign matter incorporation and discoloration before administration. Do not use one vial for more than one patient as this medicine and diluent do not contain preservative.

[Dilution table]

 

Added diluent
(0.9% sodium chloride injection)

Concentration in the dissolved state
(U / 0.1 ml)

1.0 mL
2.0 ml
4.0 ml
8.0 ml

10.0 U
5.0i
2.5 U
1.25 U

 

Note: This dilution is calculated based on 0.1 ml injection. The dose can be increased or decreased by increasing or decreasing the dose.
0.05 ml (50% reduction in dose) – 0.15 ml (50% increase in dose)

[How to save]

 

Storage container, refrigerated (2 ~ 8 ℃) Storage

[date of use]

 

36 months from date of manufacture

 

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